DNA methylation profiles across different brain regions in Alzheimer disease mice models. Mus musculus

Genome wide DNA methylation profiling of normal and disease samples from different mice models. A custom Illumina Golden Gate DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 800 CpGs. Overall design: Bisulphite converted DNA from the 35 samples were hybridised to the Illumina custom golden gate DNA methylation array.

不同小鼠模型来源的正常与疾病样本的全基因组DNA甲基化谱分析。本研究采用定制化Illumina GoldenGate DNA甲基化微珠芯片（Beadchip），获取覆盖约800个CpG位点的DNA甲基化谱。实验设计概述：将35份样本经亚硫酸氢盐转化（Bisulphite conversion）后的DNA，与定制化Illumina GoldenGate DNA甲基化芯片进行杂交。