Palladium-Catalyzed C−P Coupling Reactions between Vinyl Triflates and Phosphine−Boranes: Efficient Access to Vinylphosphine−Boranes

Vinylphosphine−borane complexes are easily synthesized
by palladium-catalyzed C−P cross-coupling of vinyl triflates
with secondary phosphine−boranes. This method allows the
synthesis of phosphine derivatives not always easily accessible by other approaches. The vinylphosphine derivatives
are purified by chromatography on silica gel. The versatility
of the method is proved by using various triflates and diaryl-,
dialkyl- and alkylarylphosphine−borane precursors. Chiral
enantiopure phosphine−boranes are synthesized from chiral
triflates.

乙烯基膦-硼烷配合物可通过钯催化的三氟甲磺酸乙烯酯与二级膦-硼烷的C-P交叉偶联反应便捷合成。该方法可合成其他途径往往难以获得的膦衍生物。所得乙烯基膦衍生物可通过硅胶柱层析进行纯化。通过使用多种三氟甲磺酸酯以及二芳基、二烷基和烷基芳基膦-硼烷前驱体，验证了该方法的普适性。利用手性三氟甲磺酸酯可合成手性对映纯膦-硼烷化合物。