The oncogenic FOXL2 mutation C134W is the sole driver of granulosa cell tumors in mice

We have generated a humanized Foxl2 mouse model by genome editing to evaluate in vivo the role of mutated FOXL2 in the development of murine Adult Granulosa Cell Tumors Comparative of genes dysregulated in mAGCTs compared to normal ovaries after RNAseq experiment

本研究通过基因组编辑技术构建了人源化Foxl2小鼠模型，旨在体内评估突变型FOXL2在小鼠成年颗粒细胞瘤（murine Adult Granulosa Cell Tumors，mAGCT）发生发展中的作用；并通过RNA测序（RNA-seq）实验，对比分析小鼠成年颗粒细胞瘤与正常卵巢组织中失调基因的表达差异。