Temporal gene expression profiling of murine epididymal infiltrating macrophages (SVCs) with different diet regimens [epididymal SVCs]

In the present study, we used C57BL/6J mouse, as a model for studying diet-induced diabetes and obesity, since this strain accumulates adipose tissue mass, insulin resistance, hyper-insulinemia, and hyper-lipidemia similar to humans fed on an high-fat high-sugar diet (HFHSD). This dataset consists of gene expression changes in epididymal infiltrating macrophages(SVCs). It consists of three biological replicates for the low-fat control diet (LFC), high-fat diet (HFC), and three different doses (5 µg, 20µg and 75 µg) of ethano-botanical formulation Kal-1 with HFC diet.

本研究选用C57BL/6J小鼠作为饮食诱导糖尿病与肥胖的研究模型，因该品系小鼠在饲喂高脂高糖饮食（high-fat high-sugar diet, HFHSD）后，可出现与人类高脂高糖饮食饲喂者相似的脂肪组织蓄积、胰岛素抵抗、高胰岛素血症及高脂血症。本数据集涵盖附睾浸润巨噬细胞（SVCs）的基因表达变化数据，其中低脂对照饮食（LFC）组、高脂饮食（HFC）组，以及配合HFC饮食分别给予5μg、20μg、75μg三种剂量乙醇基植物制剂Kal-1的组别，均设置了3个生物学重复。