Data for the article entitled: 3D-printed polycaprolactone implants modified with bioglass and Zn-doped bioglass

Files include the data presented in the manuscript entitled "3D-printed polycaprolactone implants modified with bioglass and Zn-doped bioglass " by I.Rajzer et al. (Materials 2023, 16(3), 1061; https://doi.org/10.3390/ma16031061).In this work, composite filaments in the form of sticks and 3D-printed scaffolds were investigated as a future component of an osteochondral implant. The first part of the work focused on the development of a filament modified with bioglass (BG) and Zn-doped BG obtained by injection molding. The main outcome was the manufacture of bioactive, strong, and flexible filament sticks of the required length, diameter, and properties. Then, sticks were used for scaffold production. We investigated the effect of bioglass addition on the samples mechanical and biological properties. The samples were analyzed by scanning electron microscopy, optical microscopy, infrared spectroscopy, and microtomography. The effect of bioglass addition on changes in the SBF mineralization process and cell morphology was evaluated. The presence of a spatial microstructure within the scaffolds affects their mechanical properties by reducing them. The tensile strength of the scaffolds compared to filaments was lower by 58–61%. In vitro mineralization experiments showed that apatite formed on scaffolds modified with BG after 7 days of immersion in SBF. Scaffold with Zn-doped BG showed a retarded apatite formation. Innovative 3D-printing filaments containing bioglasses have been successfully applied to print bioactive scaffolds with the surface suitable for cell attachment and proliferation.Data (.txt. and .xlsx) includes:1)   Parameters of the injection process of PCL, PCL_BG and PCL_BG_Zn blends (Table 1)2)   Printing process parameters for PCL, PCL_BG, and PCL_BG_Zn filaments (Table 2)3)   Mechanical properties of PCL stick filaments: PCL, PCL_BG, PCL_BG_Zn (Table 3)4)   Mechanical properties of scaffolds made of PCL stick filaments: PCL, PCL_BG, PCL_BG_Zn (Table 4)5)   Calculation results based on µCT images (Table 5)6)   EDX analysis of PCL_BG (Fig. 3e) and PCL_BG_Zn (Fig 3g) filaments7)   ATR_FTIR spectra of filaments and powders (Fig 4)8)   The topographical scaffolds properties (Fig 5b)9)   EDX analysis of the scaffolds after 7 days of incubation in SBF (Fig 6d, 6e, 6f)10) Histogram of the distribution of PCL_BG particles before and after incubation in SBF (Fig 7e, 7f) (Structure thickness distribution)11) Cell viability MTT test results (Fig 9)

本数据集涵盖I.Rajzer等人发表于《Materials》2023年第16卷第3期第1061页的论文《3D打印改性生物玻璃与掺锌生物玻璃的聚己内酯植入物》（https://doi.org/10.3390/ma16031061）中呈现的相关数据。
本研究以棒状复合丝材及3D打印支架为研究对象，探讨其作为骨软骨植入体未来组件的可行性。研究第一部分聚焦于通过注塑成型制备的生物玻璃（bioglass, BG）及掺锌生物玻璃（Zn-doped BG）改性丝材的开发，最终成功制备出符合指定长度、直径与性能要求的生物活性、高强度且柔韧的丝材棒。随后以该丝材制备支架，探究生物玻璃添加量对样品力学与生物学性能的影响。研究采用扫描电子显微镜（scanning electron microscopy, SEM）、光学显微镜、红外光谱及显微CT（microtomography, µCT）对样品进行表征，并评估了生物玻璃添加对模拟体液（simulated body fluid, SBF）矿化过程及细胞形态变化的影响。
研究发现，支架的空间微观结构会降低其力学性能：相较于丝材，支架的拉伸强度降低了58%~61%。体外矿化实验结果显示，在SBF中浸泡7天后，BG改性支架表面可形成磷灰石，而掺锌BG改性支架的磷灰石形成过程受到延缓。本研究成功将含生物玻璃的创新3D打印丝材用于制备具备适宜细胞附着与增殖表面的生物活性支架。
本数据集包含的.txt与.xlsx文件涵盖以下内容：
1. 聚己内酯（polycaprolactone, PCL）、PCL_BG及PCL_BG_Zn共混物的注塑工艺参数（表1）
2. PCL、PCL_BG及PCL_BG_Zn丝材的3D打印工艺参数（表2）
3. PCL、PCL_BG、PCL_BG_Zn三种棒状丝材的力学性能（表3）
4. 以PCL棒状丝材制备的PCL、PCL_BG、PCL_BG_Zn三种支架的力学性能（表4）
5. 基于µCT图像的计算结果（表5）
6. PCL_BG（图3e）与PCL_BG_Zn（图3g）丝材的能谱分析（energy-dispersive X-ray spectroscopy, EDX）结果
7. 丝材与粉体的衰减全反射傅里叶变换红外光谱（attenuated total reflection-Fourier transform infrared spectroscopy, ATR-FTIR）谱图（图4）
8. 支架的表面形貌性能（图5b）
9. 在SBF中孵育7天后的支架的EDX分析结果（图6d、6e、6f）
10. PCL_BG颗粒在SBF中孵育前后的粒径分布直方图（结构厚度分布，图7e、7f）
11. 细胞活力MTT（噻唑蓝）检测结果（图9）