Sequence of mouse mdr1a (Abcb1a; GenBank accession No.: NC_000071.5) promoter.

The transcriptional initiation site is designated by the number +1.The fragment spanning −1000 to -1 was fused to the luciferase gene in the pGL3-Basic vector (forming pGL3-mdr1a-luc). Putative NF-κB binding site is located at -550∼-540.Sequence of mouse mdr1a (Abcb1a; GenBank accession No.: NC_000071.5) promoter.转录起始位点以+1编号进行标注。将跨度为−1000至−1的片段与pGL3-Basic载体中的荧光素酶基因融合，构建得到pGL3-mdr1a-luc。推测的核因子κB（NF-κB）结合位点位于−550~−540区域。该序列为小鼠mdr1a（Abcb1a；GenBank登录号：NC_000071.5）的启动子序列。