Klebsiella pneumoniae subsp. pneumoniae KPB-1 Genome sequencing and assembly. Klebsiella pneumoniae subsp. pneumoniae KPB-1

KPB-1 is an isolate representative of KPC-producing Klebsiella pneumoniae circulating in the Italian hospitals since 2009 and obtained from the blood culture of an inpatient admitted to the ICU of St. Orsola University Hospital of Bologna, Italy. The isolate, carrying the blaKPC-3 beta-lactamase and belonging in sequence type 512, is resistant to most antibiotics including beta-lactams, fluoroquinolones, aminoglycosides and tetracyclines, but susceptible to colistin. Isolate KPB-2, obtained from the same patient, showed an identical PFGE profile, and a very similar antibiotic susceptibility pattern, but was resistant to colistin.

KPB-1是自2009年起在意大利医院中流行的产KPC型碳青霉烯酶肺炎克雷伯菌（KPC-producing Klebsiella pneumoniae）的代表性分离株，其分离自意大利博洛尼亚圣奥尔索拉大学医院重症监护病房（ICU）一名住院患者的血液培养物。该分离株携带blaKPC-3型β-内酰胺酶（blaKPC-3 beta-lactamase），隶属于序列型512（sequence type 512），对包括β-内酰胺类、氟喹诺酮类、氨基糖苷类及四环素类在内的多数抗生素耐药，但对粘菌素（colistin）敏感。从同一患者体内分离得到的KPB-2分离株，其脉冲场凝胶电泳（PFGE）图谱与KPB-1完全一致，抗生素敏感性谱也极为相似，但对粘菌素耐药。