Transcriptomic profiling of FOLR2 high and FOLR2 low CD169 positive uterine macrophage subsets from virgin mice by bulk RNA sequencing

This dataset reports bulk RNA sequencing profiles of two uterine macrophage subsets, FOLR2 high CD169 positive and FOLR2 low CD169 positive cells, purified by fluorescence activated cell sorting from the uteri of virgin mice. Total RNA extracted from each subset was subjected to RNA sequencing to characterize subset specific transcriptional programs. Comparative transcriptomic analysis identifies genes associated with Folr2 expression and reveals differences between FOLR2 high and FOLR2 low CD169 positive macrophages. These data provide a resource for studies of uterine immune regulation and reproductive biology.

本数据集报道了两种子宫巨噬细胞亚群的批量RNA测序（bulk RNA sequencing）图谱：FOLR2高表达CD169阳性细胞与FOLR2低表达CD169阳性细胞，二者均通过荧光激活细胞分选（fluorescence activated cell sorting, FACS）从未生育小鼠的子宫中纯化得到。从每个亚群中提取的总RNA经RNA测序，以表征各亚群特异性的转录程序。比较转录组学分析鉴定出与FOLR2表达相关的基因，并揭示了FOLR2高表达与低表达CD169阳性巨噬细胞之间的转录差异。本数据集为子宫免疫调控及生殖生物学研究提供了宝贵的研究资源。