Profiling molecular heterogeneity in human primary microglia

In the brain the cells that control inflammation are called a type of white blood cell called microglia. Microglia are located throughout the brain and spinal cord and account for 10–15% of all cells found within the brain. As the resident white blood cells, they are the main active immune defence in the central nervous system (CNS). Microglia are part of an important class of cells known as macrophages that have two main states: M1 and M2. M1 cells are pro- inflammatory, leading to more inflammation, while M2 are anti-inflammatory, and drive wound healing. In this study, we will collect primary microglia from surgical biospies of 100 individuals.

This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/EGA study EGAS00001002494

大脑中调控炎症反应的细胞属于一类白细胞，即小胶质细胞（microglia）。小胶质细胞广泛分布于大脑与脊髓之中，约占大脑总细胞数的10%至15%。作为中枢神经系统（central nervous system, CNS）内的常驻白细胞，它们是该系统主要的活动性免疫防御力量。小胶质细胞属于一类名为巨噬细胞的重要细胞类群，该类群存在两种主要功能状态：M1型与M2型。其中M1型细胞具有促炎特性，可加剧炎症反应；而M2型细胞则具备抗炎功能，能够促进伤口愈合。本研究将从100名受试者的手术活检样本中分离原代小胶质细胞。

本数据集属于预发布数据。若需了解威康桑格研究所（Wellcome Trust Sanger Institute）共享的预发布数据的规范使用方式（包括任何出版延期相关细则），请访问：http://www.sanger.ac.uk/datasharing/，本研究对应的EGA项目编号为EGAS00001002494