Loss of MMP-8 accelerates tumor onset; promotes progression, tumor size and lung macrometastases in the MMTV-PyMT model.
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A) Detection of first palpable tumors of MMTV-PyMT; Mmp8 wild-type (WT, n = 17), MMTV-PyMT; Mmp8 heterozygote (HET, n = 30) and MMTV-PyMT; Mmp8 null (KO, n = 10) mice. Mean ± sem, 2-tailed unpaired t-test; * p 1 cm) at 10 weeks of age for MMTV-PyMT; Mmp8 wild-type (WT, n = 26), MMTV-PyMT; Mmp8 heterozygote (HET, n = 34) and MMTV-PyMT; Mmp8 null (KO, n = 21) mice; and at 14 weeks of age for MMTV-PyMT; Mmp8 wild-type (WT, n = 22), MMTV-PyMT; Mmp8 heterozygote (HET, n = 30) and MMTV-PyMT; Mmp8 null (KO, n = 16) mice. Chi-square test, * p
A) 本实验检测了MMTV-PyMT; 基质金属蛋白酶8（Mmp8）野生型（WT，n=17）、MMTV-PyMT; Mmp8杂合子（HET，n=30）及MMTV-PyMT; Mmp8敲除（KO，n=10）小鼠的首个可触诊肿瘤发生情况。实验数据以均值±标准误（SEM）表示，采用双侧非配对t检验；* p 统计10周龄的MMTV-PyMT; Mmp8野生型（WT，n=26）、MMTV-PyMT; Mmp8杂合子（HET，n=34）及MMTV-PyMT; Mmp8敲除（KO，n=21）小鼠的直径≥1 cm肿瘤发生率；并针对14周龄的MMTV-PyMT; Mmp8野生型（WT，n=22）、MMTV-PyMT; Mmp8杂合子（HET，n=30）及MMTV-PyMT; Mmp8敲除（KO，n=16）小鼠开展同类统计。实验采用卡方检验，* p
