ATN 071 Activities of Daily Living: Laundry Dataset in Neurocognitive Assessment in Youth Initiating HAART

Data from Activities of Daily Living: Laundry [CRF f16ldry]
Study Description
A prospective cohort study comparing neurocognitive functioning in four groups of youth, ages 18-24 years, with behaviorally acquired HIV infection: two groups with CD4+ T-cells greater than 350 cells/mm3 and HIV RNA equal to or greater than 1,000 copies/ml - one initiating early highly active antiretroviral therapy (HAART) (Group 1), the other not initiating treatment (Group 2); and two groups with CD4+ T-cells less than 350 cells/mm3 - one initiating HAART according to then current DHHS guidelines (Group 3), the other not initiating treatment (Group 4). Groups 2 and 3 represented standard of care. The study provided preliminary data to test the hypothesis that initiating HAART earlier than DHHS guidelines suggested at that time resulted in better neurocognitive function in comparison with no treatment or treatment initiated according to DHHS recommendations. Youth ages 18-24 years with behaviorally acquired HIV infection

日常生活活动数据：洗衣任务 [CRF f16ldry]
研究概况
本研究为一项前瞻性队列研究，针对4组18至24岁经性行为获得人类免疫缺陷病毒（HIV, Human Immunodeficiency Virus）感染的青年人群，对比其神经认知功能：
第一类为两组CD4+T细胞（CD4+ T-cells）计数>350个/mm³且HIV核糖核酸（HIV RNA）≥1000拷贝/ml的人群：其中一组接受早期高效抗反转录病毒治疗（Highly Active Antiretroviral Therapy，HAART），记为第1组；另一组未启动治疗，记为第2组；
第二类为两组CD4+T细胞计数<350个/mm³的人群：其中一组按照当时美国卫生与人类服务部（Department of Health and Human Services，DHHS）指南启动HAART治疗，记为第3组；另一组未启动治疗，记为第4组。
第2组与第3组代表当时的临床标准治疗方案。
本研究通过前瞻性队列数据验证了一项假说：相较于未接受治疗或按照当时DHHS指南启动治疗的人群，提前启动HAART治疗可获得更优的神经认知功能。
研究对象为18至24岁经性行为获得HIV感染的青年。