Table_1_Incidence, Morbidity and years Lived With Disability due to Type 2 Diabetes Mellitus in 204 Countries and Territories: Trends From 1990 to 2019.docx

BackgroundWe aimed to examine the descriptive epidemiology and trends in the burden of type 2 diabetes mellitus (T2DM).
MethodsData were extracted from the Global Burden of Disease 2019 dataset. Estimated annual percentage changes (EAPCs) were calculated to assess the trends in incidence rate, mortality and disability-adjusted life-years (DALYs) associated with T2DM. Measures were stratified by sex, region, country, age and social development index (SDI) value.
ResultsThe global age-standardized incidence rate of T2DM increased from 1990 to 2019, with an EAPC of 1.25 (95% CI, 1.19 to 1.31). In 2019, the highest age-standardized incidence rate of T2DM was observed in high-SDI regions, and the largest increase in this rate from 1990 to 2019 was also in high-SDI regions (EAPC, 1.74;95% CI, 1.57 to 1.90). At the regional level, Central Asia (EAPC, 2.53;95% CI, 2.45 to 2.61) had the largest increase in the age-standardized incidence rate of T2DM from 1990 to 2019. At the national level, Luxembourg (EAPC, 4.51;95% CI, 4.37 to 4.65) and Uzbekistan (EAPC, 3.63; 95% CI, 3.44 to 3.82) had the largest increases in the age-standardized incidence rate of T2DM from 1990 to 2019. The global age-standardized death and DALY rates increased from 1990 to 2019, with EAPCs of 0.26 (95% CI, 0.16 to 0.37) and 0.81 (95% CI, 0.77 to 0.85), respectively. The age-standardized death and DALY rates showed the largest increases in Central Asia, South Asia and Southern Sub-Saharan Africa.
ConclusionsGlobally, the age-standardized incidence, death and DALY rates increased from 1990 to 2019. Central Asia, South Asia and Southern Sub-Saharan Africa were found to have the greatest burden of T2DM. Future strategies should focus on these high-risk regions and other high-risk populations.

研究背景：本研究旨在探讨2型糖尿病（type 2 diabetes mellitus, T2DM）的描述性流行病学特征及其疾病负担变化趋势。
研究方法：本研究数据来源于《2019年全球疾病负担》（Global Burden of Disease 2019）数据集。通过计算估计年度百分比变化（estimated annual percentage changes, EAPCs），以评估与2型糖尿病相关的发病率、死亡率及伤残调整寿命年（disability-adjusted life-years, DALYs）的变化趋势。研究分层维度包括性别、区域、国家、年龄组及社会发展指数（social development index, SDI）分值。
研究结果：1990年至2019年，全球2型糖尿病年龄标化发病率呈上升态势，估计年度百分比变化为1.25（95% CI：1.19~1.31）。2019年，高社会发展指数（high-SDI）地区的2型糖尿病年龄标化发病率最高；1990至2019年间，该发病率增幅最大的区域同样为高社会发展指数地区（EAPC=1.74；95% CI：1.57~1.90）。区域层面分析显示，中亚地区（EAPC=2.53；95% CI：2.45~2.61）的2型糖尿病年龄标化发病率在1990至2019年间增幅最为显著。国家层面来看，卢森堡（EAPC=4.51；95% CI：4.37~4.65）与乌兹别克斯坦（EAPC=3.63；95% CI：3.44~3.82）的2型糖尿病年龄标化发病率增幅位居全球前列。1990年至2019年，全球年龄标化死亡率及伤残调整寿命年率均有所升高，对应的估计年度百分比变化分别为0.26（95% CI：0.16~0.37）与0.81（95% CI：0.77~0.85）。年龄标化死亡率与伤残调整寿命年率增幅最大的区域为中亚、南亚及撒哈拉以南非洲南部地区。
研究结论：1990年至2019年，全球2型糖尿病的年龄标化发病率、死亡率及伤残调整寿命年率均呈上升趋势。中亚、南亚及撒哈拉以南非洲南部地区的2型糖尿病疾病负担最为沉重。未来的防控策略应重点聚焦上述高风险区域及其他高危人群。