Assessment of cardiovascular risk factors in patients with Knee Osteoarthritis

Background: Osteoarthritis and cardiovascular disease (CVD) are prevalent in India. However, there is dearth of literature among Indians studying the relationship between the two. This study was carried out to assess various cardiovascular (CV) risk factors in patients with knee osteoarthritis (OA) with an objective to investigate their association, screening and management. 

Methods: In total, 225 patients were included in this cross-sectional study. Participants were diagnosed with knee OA on the basis of  Kellgren and Lawrence (K-L) classification of their radiograph. Participants were also assessed for CV risk factors (age, BMI, systolic BP, diabetes mellitus, total cholesterol, HDL, smoking) with the help of the Joint British Society QRisk3 calculator (JBS3), which gave three variables: JBS3 risk score, heart age, life expectancy. Chi Square and Anova p test were used to compare the variables. Pearson’s correlation coefficient was used to find out the relationship between CV ris...

背景：骨关节炎（Osteoarthritis, OA）与心血管疾病（cardiovascular disease, CVD）在印度人群中具有较高患病率，但目前针对印度人群开展的二者关联相关研究文献较为匮乏。本研究旨在评估膝关节骨关节炎（knee osteoarthritis, OA）患者的各类心血管（cardiovascular, CV）危险因素，以探究二者的关联、筛查方案及管理策略。

方法：本研究为横断面研究，共纳入225例受试者。所有受试者均根据其影像学X线片的Kellgren-Lawrence（K-L）分级标准确诊为膝骨关节炎。同时，借助英国联合学会QRisk3风险计算器（Joint British Society QRisk3 calculator, JBS3）对受试者的CV危险因素进行评估，涵盖年龄、体质量指数（Body Mass Index, BMI）、收缩压、糖尿病、总胆固醇、高密度脂蛋白胆固醇（High-Density Lipoprotein, HDL）及吸烟史，该计算器可生成三项指标：JBS3风险评分、心脏年龄与预期寿命。采用卡方检验与方差分析对各变量进行比较，采用Pearson相关系数以探究CV风险[原文截断]。