Chemoselective Transfer Hydrogenation of α,β-Unsaturated Ketones Catalyzed by Pincer-Pd Complexes Using Alcohol as a Hydrogen Source

A pincer-Pd complex was utilized in the chemoselective transfer hydrogenation of α,β-unsaturated ketones using n-BuOH as a hydrogen source and solvent. Good to excellent yields were obtained for various substrates even with reducible groups. Based on deuterium-labeling experiments, the reaction mechanism is proposed to occur via a pincer-Pd-hydride intermediate.本研究采用钳形钯配合物（pincer-Pd complex），以正丁醇（n-BuOH）作为氢源与反应溶剂，实现了α,β-不饱和酮（α,β-unsaturated ketones）的化学选择性转移氢化（chemoselective transfer hydrogenation）反应。即便底物（substrates）带有可还原基团（reducible groups），各类底物均可获得良好至优异的反应收率。基于氘标记实验（deuterium-labeling experiments）结果，该反应的反应机理（reaction mechanism）被推测为经由钳形钯氢中间体（pincer-Pd-hydride intermediate）进行。