The societal impact of early intensified treatment in patients with type 2 diabetes mellitus: Supplementary material

Aim: The current study estimates the societal impact of early intensified treatment compared with initial monotherapy with subsequent treatment intensification in newly diagnosed adults with type 2 diabetes mellitus in Mexico. Methods: An individual patient-level simulation and a static cohort model were employed to simulate the treatment pathway and the probability of experiencing complications of diabetes. The avoided number of events was translated into avoided productivity losses, which were monetized using wages. Results: Patients on early intensified treatment experienced approximately 13,000 fewer complication events over 10 years. This was translated into a societal impact of $54 million (USD). Conclusion: Early treatment intensification is likely to be of particular benefit to health outcomes and productivity losses.

研究目的：本研究旨在对比早期强化治疗与初始单药治疗后序贯强化治疗，评估二者对墨西哥新确诊成年2型糖尿病（type 2 diabetes mellitus）患者的社会影响。研究方法：本研究采用个体患者水平模拟模型与静态队列模型，模拟糖尿病患者的治疗路径及并发症发生概率。将避免发生的事件数换算为避免的生产力损失，并以工资水平对该损失进行货币化计量。研究结果：接受早期强化治疗的患者在10年随访期内的并发症发生事件数较对照组减少约13000例，由此带来的社会影响折合5400万美元（USD）。研究结论：早期治疗强化或可显著改善患者健康结局，并减少生产力相关损失。