Total Syntheses of (+)-Lyconadin A and (−)-Lyconadin B

The enantioselective syntheses of (+)-lyconadin A and (−)-lyconadin B are described. Key bond constructions include a strategy-level intramolecular aldol/conjugate addition cascade, an olefin aminoiodination, and a novel one-pot α-pyridinone annulation.本研究报道了(+)-石松定碱A与(−)-石松定碱B的对映选择性全合成。核心化学键构筑策略涵盖：策略级分子内羟醛/共轭加成级联反应、烯烃氨基碘化反应，以及一种新型一锅法α-吡啶酮环化反应。