Salivary arginase activity after mechanical-chemical therapy

Abstract Introduction Salivary components can be used as biomarkers for diagnosing and monitoring oral diseases. There is evidence that one potential biomarker, arginase, is associated with the inflammatory processes of periodontal disease, and its enzymatic activity is reduced according to the improvement in the clinical parameters after treatment. Objective The present study aimed to evaluate the salivary arginase activity in gingivitis and periodontitis patients treated with full-mouth mechanical procedures combined with the adjunctive use of essential oils or chlorhexidine mouthwash, respectively. Material and method Twenty-six gingivitis and 16 periodontitis patients received complete periodontal examinations at the baseline and 3 months after therapy, in which the periodontal probing depth, clinical attachment loss, plaque index, and gingival index measurements were taken. At these same appointments, the salivary total protein level and salivary arginase activity were also established via spectrophotometry. Result There were improvements in all of the clinical parameters (p摘要 引言 唾液成分可作为诊断与监测口腔疾病的生物标志物（biomarker）。已有研究证实，潜在生物标志物精氨酸酶（arginase）与牙周疾病的炎症进程密切相关，且其酶活性会随治疗后临床指标的改善而降低。 研究目的 本研究旨在评估两类患者的唾液精氨酸酶活性：一类为接受全口机械治疗联合辅助使用精油的牙龈炎患者，另一类为接受全口机械治疗联合辅助使用氯己定漱口水的牙周炎患者。 材料与方法 本研究纳入26名牙龈炎患者与16名牙周炎患者，分别于治疗前基线状态与治疗后3个月完成全面牙周检查，记录牙周探诊深度、临床附着丧失、菌斑指数及牙龈指数。同时在上述两次随访时点，采用分光光度法检测受试者的唾液总蛋白水平与唾液精氨酸酶活性。 结果 所有临床指标均得到改善（p