Table_1_Effect of Microvascular Invasion on the Prognosis in Hepatocellular Carcinoma and Analysis of Related Risk Factors: A Two-Center Study.XLS

Objective: Microvascular invasion is considered to initiate intrahepatic metastasis and postoperative recurrence of hepatocellular carcinoma (HCC). We aimed to analyze the effect of MVI on the prognosis in HCC and identify related risk factors for microvascular invasion (MVI).
Methods: The clinical data of 553 HCC patients who underwent liver surgery at Qingdao University from January 2014 to December 2018 and 89 patients at Beijing Tsinghua Changgung Hospital treated between October 2014 and October 2019 were collected retrospectively. We explored the impact of MVI on the prognosis of patients with HCC using Kaplan-Meier analysis. We conducted logistic regression analysis to identify variables significantly related to MVI.
Results: Pathological examination confirmed the presence of MVI in 265 patients (41.3%). Six factors independently correlated with MVI were incorporated into the multivariate logistic regression analysis: Edmondson-Steiner grade [odds ratio (OR) = 3.244, 95%CI: 2.243–4.692; p < 0.001], liver capsule invasion (OR = 1.755; 95%CI: 1.215–2.535; p = 0.003), bile duct tumor thrombi (OR = 20.926; 95%CI: 2.552–171.553; p = 0.005), α-fetoprotein (> 400 vs. < 400 ng/ml; OR = 1.530; 95%CI: 1.017–2.303; p = 0.041), tumor size (OR = 1.095; 95%CI: 1.027–1.166; p = 0.005), and neutrophil-lymphocyte ratio (OR = 1.086; 95%CI: 1.016–1.162; p = 0.015). The area under the receiver operating characteristic curve (AUC) was 0.743 (95%CI: 0.704–0.781; p < 0.001), indicating that our logistic regression model had significant clinical usefulness.
Conclusions: We analyzed the effect of MVI on the prognosis in HCC and evaluated the risk factors for MVI, which could be helpful in making decisions regarding patients with a high risk of recurrence.

研究目的：微血管侵犯（microvascular invasion, MVI）被认为是启动肝细胞癌（hepatocellular carcinoma, HCC）肝内转移与术后复发的关键因素。本研究旨在分析MVI对肝细胞癌患者预后的影响，并明确与微血管侵犯相关的危险因素。
研究方法：回顾性收集2014年1月至2018年12月于青岛大学接受肝脏手术的553例肝细胞癌患者，以及2014年10月至2019年10月于北京清华长庚医院接受治疗的89例肝细胞癌患者的临床资料。采用Kaplan-Meier分析探讨MVI对肝细胞癌患者预后的影响；通过logistic回归分析筛选与MVI显著相关的变量。
研究结果：经病理检查证实，265例患者存在MVI，占比41.3%。将与MVI独立相关的6项因素纳入多因素logistic回归分析，分别为：Edmondson-Steiner分级（比值比[odds ratio, OR]=3.244，95%置信区间[95% confidence interval, 95%CI]=2.243~4.692；P<0.001）、肝包膜侵犯（OR=1.755，95%CI=1.215~2.535；P=0.003）、胆管癌栓（bile duct tumor thrombi，OR=20.926，95%CI=2.552~171.553；P=0.005）、甲胎蛋白（α-fetoprotein，>400 ng/ml 与 <400 ng/ml；OR=1.530，95%CI=1.017~2.303；P=0.041）、肿瘤直径（OR=1.095，95%CI=1.027~1.166；P=0.005）以及中性粒细胞与淋巴细胞比值（neutrophil-lymphocyte ratio，OR=1.086，95%CI=1.016~1.162；P=0.015）。受试者工作特征曲线下面积（area under receiver operating characteristic curve, AUC）为0.743（95%CI=0.704~0.781；P<0.001），表明本研究构建的logistic回归模型具有显著的临床应用价值。
研究结论：本研究分析了MVI对肝细胞癌患者预后的影响，并评估了MVI的相关危险因素，可为高复发风险肝细胞癌患者的临床决策提供参考依据。