Supplementary file 1_Reorganization of brain networks in olfactory groove meningioma patients: a pilot resting-state fMRI study.docx

BackgroundOlfactory groove meningioma (OGM) is frequently associated with neuropsychological and behavioral impairments. However, there is currently a lack of evidence on the pathobiology of these functional alterations. In this study, our objective was to evaluate functional connectivity disturbances in patients with OGMs compared to healthy controls.
MethodsNineteen patients with OGMs and twenty healthy controls were enrolled. The seed-based functional connectivity analysis used the main hubs of the default mode network (DMN), salience network (SN), and fronto-parietal network (FPN) as seeds. Region-of-interest (ROI)-to-voxel second-level analysis was conducted, revealing the most significant clusters of differences in brain functional connectivity between the groups.
ResultsPatients with OGMs demonstrated significant alterations in resting-state functional connectivity within the DMN, SN, and FPN compared to controls. Specifically, within the DMN, we identified abnormal connectivity patterns involving the medial prefrontal cortex bilaterally, posterior cingulate cortex bilaterally, and right posterolateral cortex. In the SN, we observed enhanced functional connectivity between the anterior cingulate cortex bilaterally and left frontal, temporal, and insular regions. Additionally, the FPN exhibited disrupted connectivity of the right posterior parietal cortex with other brain areas. Notably, some connectivity changes were related to perilesional edema volume, visual acuity, and clinical metrics (KPS and MoCA scores).
ConclusionWe revealed significant alterations in DMN, SN, and FPN function in patients with olfactory groove meningiomas compared with controls. These changes were associated with clinical variables and lesion characteristics. To our knowledge, this is the first report on rs-fMRI alterations in patients with olfactory groove meningiomas.

背景：嗅沟脑膜瘤（Olfactory groove meningioma, OGM）常伴随神经心理与行为功能损害，但目前尚缺乏此类功能改变的病理生物学相关证据。本研究旨在对比嗅沟脑膜瘤患者与健康对照者的脑功能连接异常情况。
方法：本研究纳入19例嗅沟脑膜瘤患者及20名健康对照者。采用基于种子点的功能连接分析，以默认模式网络（default mode network, DMN）、突显网络（salience network, SN）及额顶网络（fronto-parietal network, FPN）的核心节点作为种子区域。随后开展感兴趣区（region-of-interest, ROI）-体素水平的二级分析，以明确两组间脑功能连接差异最显著的聚类簇。
结果：与健康对照相比，嗅沟脑膜瘤患者的默认模式网络、突显网络及额顶网络的静息态功能连接均存在显著异常。具体而言，在默认模式网络中，我们发现双侧内侧前额叶皮层、双侧后扣带回皮层及右侧后外侧皮层的连接模式存在异常；在突显网络中，双侧前扣带回皮层与左侧额叶、颞叶及岛叶区域之间的功能连接增强；此外，额顶网络可见右侧后顶叶皮层与其他脑区的连接受损。值得注意的是，部分连接异常与病灶周围水肿体积、视力水平及临床指标（卡氏功能状态评分KPS与蒙特利尔认知评估量表MoCA评分）相关。
结论：本研究揭示了嗅沟脑膜瘤患者相较于健康对照，其默认模式网络、突显网络及额顶网络功能存在显著异常，且此类改变与临床变量及病灶特征密切相关。据我们所知，本研究是首项针对嗅沟脑膜瘤患者静息态功能磁共振成像（resting-state functional magnetic resonance imaging, rs-fMRI）异常改变的报道。