Cox regression models containing univariate and multivariate analyses of factors related to time to the first acute or progressive clinical event.

*Adjusted for Center and date of RIS diagnosis.HR = hazard ratio; CSF = cerebrospinal fluid.§ = IgG index >0.7 or the presence of >2 unique oligoclonal bands within the CNS.*已针对诊断中心及RIS确诊时间进行校正。风险比（HR, hazard ratio）；脑脊液（CSF, cerebrospinal fluid）。§：免疫球蛋白G（IgG）指数大于0.7，或中枢神经系统（CNS）内存在2种以上独特寡克隆带。