Belgium BAG

The Belgium BAG includes groups situated at four Flemish universities: Antwerpen, Brussels, Ghent and Leuven. The proposed projects are highly diverse, including viral, prokaryotic and eukaryotic proteins with a strong focus on targets and processes of biomedical relevance. Many projects deal with membrane proteins, cell surface receptors and protein-protein complexes. Central to the research in the BAG associated groups is the employment of integrative methods in structural biology combining X-ray crystallography, SAXS, and electron microscopy. Many crystals in the various proposed projects are small in size and radiation sensitive, requiring the use of the high brilliance MX beam lines, preferably with micro-focused X-rays.

比利时BAG数据集涵盖了依托四所弗拉芒语区大学的研究团队，分别为安特卫普大学、布鲁塞尔大学、根特大学与鲁汶大学。本次拟开展的研究项目多样性显著，涵盖病毒蛋白、原核生物蛋白与真核生物蛋白，且高度聚焦具有生物医学研究价值的靶点与研究流程。诸多项目围绕膜蛋白、细胞表面受体以及蛋白质-蛋白质复合物展开研究。BAG关联研究团队的核心研究手段，是采用结构生物学整合研究方法，结合X射线晶体学（X-ray crystallography）、小角X射线散射（SAXS）与电子显微镜技术。本次各类拟开展项目中涉及的诸多晶体尺寸偏小且对辐射敏感，因此需要使用高亮度的大分子晶体学（MX）光束线，优先采用微聚焦X射线技术。