Alzheimer’s disease (AD) is a severe1 age-related neurodegenerative disorder characterized by accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles, synaptic and neuronal loss, and cog
Proliferation was measured using CSFE-loaded cells. There was an age-dependent decline in reactivity that was more pronounced in women and in people with the Alzheimer's risk marker ApoE4.
Circulating CD4+ T cells are dysfunctional in Alzheimer's disease (AD), however, the underlying molecular mechanisms are not clear. In this study, we demonstrate that CD4+ T cells from AD patients and
This study aimed to explore the molecular basis of peripheral immune cells and the features of adaptive immune repertoire at a single cell level. We pro?led 36,849 peripheral blood mononuclear cel
