Table_2_Effectiveness of Impregnated Central Venous Catheters on Catheter-Related Bloodstream Infection in Pediatrics.DOCX

BackgroundThe efficacy and safety of impregnated central venous catheters (CVCs) in pediatrics remain controversial. The purpose of this study was to evaluate the efficacy of impregnations for the prevention of catheter-related bloodstream infection (CRBSI).
MethodsWe searched the following five electronic databases: Medline, PubMed, Cochrane, Embase, and the Web of Science for randomized controlled trials (RCTs) up to March 2021. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a fixed-effects model. Assessment of publication biases was evaluated by Egger's test. Heterogeneity between studies was assessed based on the chi-square test and I2 statistics, and sensitivity analysis and subgroup analysis were also performed.
ResultsA total of six RCTs with 3,091 patients were included. Impregnated CVCs provided significant benefits in reducing the risk of CRBSI (RR = 0.41, 95% CI: 0.26–0.66) in pediatric patients, especially in the pediatric group. No publication bias was observed in the Egger test for the risk of CRBSI. Drug type is a source of heterogeneity.
ConclusionAntimicrobial-impregnated CVCs are beneficial to prevent CVC-related complications in pediatrics.

研究背景
涂层中心静脉导管（impregnated central venous catheters, CVCs）在儿科患者中的应用效果与安全性仍存在争议。本研究旨在评估涂层导管预防导管相关血流感染（catheter-related bloodstream infection, CRBSI）的效果。

研究方法
我们检索了截至2021年3月的Medline、PubMed、Cochrane、Embase及Web of Science五大电子数据库，纳入随机对照试验（randomized controlled trials, RCTs）。采用固定效应模型计算合并风险比（pooled risk ratios, RRs）及95%置信区间（95% confidence intervals, CIs）。采用Egger检验评估发表偏倚。采用卡方检验及I²统计量评估研究间异质性，并开展敏感性分析与亚组分析。

研究结果
本研究共纳入6项RCTs，涉及3091名患者。涂层CVCs可显著降低儿科患者的CRBSI发生风险（RR=0.41，95%CI：0.26~0.66），尤其在儿科亚组中效果显著。针对CRBSI发生风险的Egger检验未发现明显发表偏倚。药物类型是异质性的来源之一。

研究结论
抗菌涂层CVCs有助于预防儿科患者的CVC相关并发症。