Reactome

The cornerstone of Reactome is a freely available, open source relational database of signaling and metabolic molecules and their relations organized into biological pathways and processes. The core unit of the Reactome data model is the reaction. Entities (nucleic acids, proteins, complexes, vaccines, anti-cancer therapeutics and small molecules) participating in reactions form a network of biological interactions and are grouped into pathways. Examples of biological pathways in Reactome include classical intermediary metabolism, signaling, transcriptional regulation, apoptosis and disease. Inferred orthologous reactions are available for 15 non-human species including mouse, rat, chicken, zebrafish, worm, fly, and yeast.Reactome的核心基石是一套免费开源的关系型数据库，收录信号传导与代谢分子及其相互关系，并将这些内容整理为各类生物通路与生物学过程。Reactome数据模型的核心单元为生物反应。参与生物反应的实体（包括核酸、蛋白质、复合物、疫苗、抗癌治疗药物与小分子）构成了生物相互作用网络，并被归类至各生物通路中。Reactome收录的生物通路示例包括经典中间代谢、信号传导、转录调控、细胞凋亡以及疾病相关通路。该数据库还为15种非人类物种提供了经推断得到的同源反应，涵盖小鼠、大鼠、鸡、斑马鱼、线虫、果蝇与酵母。

搜集汇总

背景与挑战

背景概述

Reactome 是一个免费、开源的、经过人工审编和同行评审的生物通路数据库，其核心是一个关系型数据库，以反应为基本单元，组织信号传导和代谢分子及其关系，形成生物相互作用网络并归类为通路。它涵盖了多种生物学过程，如中间代谢、信号传导和疾病，并提供了包括小鼠、斑马鱼、酵母等15个非人类物种的推断直系同源反应数据。