Replication of associations with LDL-C, HDL-C, and triglycerides at novel loci.

aMeta-analysis of LDL-C, HDL-C, and TG among 12 European populations [10].
bMost significant genome-wide SNP and lipoprotein fraction(s) association at locus for tests among the 22 lipoprotein fractions. (+/−) indicates trend of fraction with increasing copies of the minor allele (same as sign of beta coefficient, see Tables 2 and S2).
cP-value (two-sided) for association in additional 4639 (all) or 3305 (fasting) samples from the WGHS (internal replication). All association trends were consistent with discovery sample. Combining these new samples with the original discovery samples leads to p–values for the extended WGHS sample. Bold font indicates p-value smaller than in main discovery sample.
dP-value and trend (+/−) for association of increasing copies of the minor allele with indicated lipoprotein fraction in either WGHS or the meta-analysis. n.s. in WGHS analysis indicates not significant (P>0.05).
eGenome-wide significant association with plasma C-reactive protein in the WGHS [21].

a. 针对12个欧洲人群中的低密度脂蛋白胆固醇（low-density lipoprotein cholesterol, LDL-C）、高密度脂蛋白胆固醇（high-density lipoprotein cholesterol, HDL-C）与甘油三酯（triglyceride, TG）开展的荟萃分析[10]。
b. 针对22种脂蛋白组分开展的关联检验中，该位点上最具统计学显著性的全基因组单核苷酸多态性（Single Nucleotide Polymorphism, SNP）与脂蛋白组分的关联结果。(+/−) 表示随着次要等位基因拷贝数增加时对应组分的变化趋势（与β系数的符号一致，详见表2与补充表S2）。
c. 针对来自全基因组健康研究（Women's Genome Health Study, WGHS）的额外4639份（全部样本）或3305份（空腹样本）进行关联检验得到的双侧P值。所有关联趋势均与发现队列一致。将这些新增样本与原始发现队列合并后，可得到扩展后WGHS样本的P值。粗体字体表示该P值小于主发现队列中的对应P值。
d. 针对WGHS或本次荟萃分析中，次要等位基因拷贝数增加与指定脂蛋白组分的关联，给出其P值与变化趋势(+/−)。WGHS分析中标注的n.s.表示无统计学显著性（P>0.05）。
e. 在WGHS中与血浆C反应蛋白存在全基因组显著性关联[21]。