Summary statistics of risk loci for all-cause dementia, AD and VD in T2D

Dementia, a critical complication of type 2 diabetes (T2D), presents significant challenges due to its poor prognosis. Despite the importance of determining the genetic background underlying diabetic complications, limited knowledge is available for T2D-related dementia. To address this knowledge gap, we conducted genome-wide association studies in 39,574 T2D participants from the UK Biobank. Risk variants and risk genes exclusive to T2D-related dementia were identified, implicating additional mechanisms for proteinopathy and disrupted lipid metabolism. Functional genomic analysis further highlighted the key roles of glucose, cholesterol metabolism, and type 2 immune dysfunction in T2D-related dementia pathogenesis. The genetic risk of T2D-related dementia was also specifically enriched in pan-limbic system structures and neurons. Based on this specific genetic background, a polygenic score was further tailored for dementia risk stratification in patients with T2D. These findings provide insights into the genetic basis of T2D-related dementia and highlight potential pathways for mechanistic investigation and diagnostics.This dataset contains all summary statistics generated during the process.