WP4742 - Ketogenesis and ketolysis - Homo sapiens

This pathway depicts several metabolic pathways involved in ketogenic diet treatment.
In hepatocytes in the liver, fatty acids (FAs) are normally transformed into acetyl-CoA, which can then enters the TCA (Krebs) cycle for energy production.
However, when FA levels are to high for the TCA cycle to be utilized completely, acetyl-CoA is used in ketogenesis and ketolysis.
These processes are a complex process of transporter proteins and several other (mitochondrial) pathways [https://www.ncbi.nlm.nih.gov/books/NBK98219/figure/masino.f1/].

本通路展示了与生酮饮食治疗相关的多条代谢通路。在肝脏的肝细胞中，脂肪酸（fatty acids, FAs）通常会转化为乙酰辅酶A（acetyl-CoA），后者随后可进入三羧酸循环（TCA，即Krebs循环）以产生能量。然而，当脂肪酸水平过高，致使三羧酸循环无法完全代谢时，乙酰辅酶A会被用于酮体生成与酮体分解过程。上述过程是一套涉及转运蛋白与其他多条（线粒体）通路的复杂生理过程 [https://www.ncbi.nlm.nih.gov/books/NBK98219/figure/masino.f1/]。