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Mettl3 regulates late retinogenesis

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Mettl3 was conditionally knocked out from retinal progenitor cells. Metll3 deficient retinas exhibited disrupted cell cycle during late retinogenesis and abnormality in retinal architecture and physiology. 2 control and 2 Mettl3-conditional knockout retinas (from the same litter at postnatal day 7) were dissociated into single cells, and processed using 10X Genomics Chrominum to prepare scRNAseq libraries. 2 control retinas were mixed together as one control sample, and 2 mutant retinas were processed together as one mutant sample.

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