Self-Reported Medication Adherence in Triggered Escalating Real-time Adherence Intervention to Promote Rapid HIV Viral Suppression among Youth Living with HIV Failing Antiretroviral Therapy: The TERA Study

ACASI items ask participants about medications they take for HIV.
Study Description
ATN 152 TERA was a multi-site two-arm RCT comparing HIV-1 RNA viral suppression and electronic dose monitored (EDM) ART adherence in youth living with HIV with detectable viral load assigned to receive either the TERA intervention or standard of care for HIV. Participants assigned to the 12-week intervention condition received 3 remote coaching sessions through video enabled conferencing and interacted via text and phone in real-time for any delayed or missed doses signaled by the participant’s EDM. The intervention was evaluated on viral suppression at week 12 and participants were followed through to week 48. Viral suppression and adherence, as well as psychosocial functioning, across the 48 weeks were also examined. The intervention did not improve viral suppression, but did improve ART adherence as measured by the EDM through week 36. Study participants included 13-24 year old youth living with HIV who failed ART therapy defined as having detectable HIV virus (HIV-1 RNA ≥200 copies/ml) within 45 days of enrollment despite having been on ART for at least 24 weeks.

ACASI条目用于询问参与者所服用的抗HIV药物相关信息。
研究概况
ATN 152 TERA是一项多中心双臂随机对照试验（RCT），旨在对比针对HIV病毒载量可检测的HIV感染者青少年的两种方案：TERA干预方案与HIV标准护理，评估二者在HIV-1 RNA病毒抑制率及电子剂量监测（electronic dose monitored, EDM）抗逆转录病毒治疗（antiretroviral therapy, ART）依从性上的差异。被分配至12周干预组的参与者，将通过视频会议获得3次远程辅导课程，并可通过短信与电话就自身电子剂量监测系统（EDM）触发的延迟或漏服药物情况进行实时互动。该干预方案以第12周的病毒抑制率作为评估终点，且对参与者的随访持续至第48周。研究同时分析了48周内的病毒抑制情况、治疗依从性及社会心理功能状态。结果显示，该干预方案未能提升病毒抑制率，但在第36周前通过电子剂量监测（EDM）评估的抗逆转录病毒治疗（ART）依从性得到了显著改善。本研究的纳入对象为13至24岁的HIV感染者青少年，且在入组前45天内，尽管已接受至少24周的抗逆转录病毒治疗（ART），但仍出现治疗失败，即HIV病毒可检测（HIV-1 RNA≥200拷贝/毫升）。