Data Sheet 1_Chlamydia psittaci pneumonia without cough: recovery, case report and literature review.pdf

ObjectivesWe report a case of Chlamydia psittaci pneumonia in a patient presenting with high fever and generalized myalgia but no cough. As infections with Chlamydia psittaci are potentially misdiagnosed and non-responsive to empirical antibiotic treatment, this report aims to enhance the awareness among the healthcare providers.
MethodsA 34-year-old male patient developed high fever and fatigue after exposure to poultry. He presented to the hospital for treatment. Chest computed tomography (CT) showed a high-density shadow in the deep area of the left lower lung. Sputum culture returned negative. Empirical treatment with multiple antibiotics was given. No improvement was observed in the patient’s condition. Next-generation sequencing (NGS) was performed on bronchoalveolar lavage fluid. It confirmed the diagnosis of Chlamydia psittaci infection. The lesion was located deeply. The clinical team promptly adjusted the antibiotic regimen. Intensive pulmonary rehabilitation training was added simultaneously. It facilitated the drainage of deep-seated sputum. The patient finally achieved complete recovery and was discharged.
ResultsThis case report indicates that in patients with high fever, clinicians should first determine the etiological factors and identify the lesion site. Accurate diagnosis can thus be achieved. In this case, the lesion was deeply located in the lung. Even with sensitive antibiotics, complete elimination of the lesion was difficult. Therefore, active pulmonary rehabilitation intervention should be implemented promptly. It promotes airway clearance, sputum excretion, and secretion drainage. It also accelerates the patient’s recovery process.

研究目的：本次报告报道1例以高热、全身肌痛为主要表现但无咳嗽症状的鹦鹉热衣原体（Chlamydia psittaci）肺炎病例。鉴于鹦鹉热衣原体感染易被误诊，且对经验性抗生素治疗应答不佳，本报告旨在提升临床医护人员对该病的认知水平。

研究方法：1例34岁男性患者在接触家禽后出现高热及乏力症状，遂就诊于我院。胸部计算机断层扫描（CT）显示左肺下叶深部区域存在高密度阴影。痰培养结果为阴性。予多种抗生素经验性治疗后，患者病情无改善。随后对支气管肺泡灌洗液行下一代测序（NGS），确诊为鹦鹉热衣原体感染。该病灶位置较深，临床团队随即调整抗生素治疗方案，并同步强化肺康复训练，以促进深部痰液引流。最终患者完全康复并出院。

研究结果：本病例报告提示，对于高热患者，临床医师应首先明确病因并确定病灶部位，以实现精准诊断。本次病例中，病灶位于肺部深部，即便使用敏感抗生素，也难以完全清除病灶。因此，需及时采取积极的肺康复干预措施，该措施可促进气道廓清、痰液排出及分泌物引流，进而加速患者康复进程。