BindingDB Entry 50018243: Fused-azepinones: Emerging scaffolds of medicinal importance.

Small molecule binding data for protein Casein kinase II subunit alpha 3, DNA topoisomerase 1, DNA topoisomerase 2-alpha, Dual specificity mitogen-activated protein kinase kinase 1, Dual specificity protein kinase CLK1, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, G1/S-specific cyclin-D2, Glycogen synthase kinase-3 alpha, Glycogen synthase kinase-3 beta, Insulin receptor, Mitogen-activated protein kinase 1, Mitogen-activated protein kinase 3, Platelet-derived growth factor receptor alpha/beta, Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase 2, Protein mono-ADP-ribosyltransferase PARP3, Proto-oncogene tyrosine-protein kinase Src, RAF proto-oncogene serine/threonine-protein kinase, Serine/threonine-protein kinase Chk1, Serine/threonine-protein kinase Chk2, and Tyrosine-protein kinase ABL1, Uniprot O14757, O96017, P00519, P04049, P05622, P06213, P09874, P11387, P11388, P12931, P18266, P26618, P27361, P28482, P30279, P49759, P49840, Q02750, Q13627, Q8NEV1, Q9UGN5, and Q9Y6F1

本数据集涵盖酪蛋白激酶II亚基α3、DNA拓扑异构酶1、DNA拓扑异构酶2α、双特异性丝裂原活化蛋白激酶激酶1、双特异性蛋白激酶CLK1、双特异性酪氨酸磷酸化调节激酶1A、G1/S特异性周期蛋白-D2、糖原合酶激酶-3α、糖原合酶激酶-3β、胰岛素受体、丝裂原活化蛋白激酶1、丝裂原活化蛋白激酶3、血小板衍生生长因子受体α/β、聚[ADP-核糖]聚合酶1、聚[ADP-核糖]聚合酶2、蛋白单ADP-核糖基转移酶PARP3、原癌基因酪氨酸蛋白激酶Src、RAF原癌基因丝氨酸/苏氨酸蛋白激酶、丝氨酸/苏氨酸蛋白激酶Chk1、丝氨酸/苏氨酸蛋白激酶Chk2以及酪氨酸蛋白激酶ABL1的小分子结合数据；上述蛋白质对应的UniProt（Uniprot）编号依次为O14757、O96017、P00519、P04049、P05622、P06213、P09874、P11387、P11388、P12931、P18266、P26618、P27361、P28482、P30279、P49759、P49840、Q02750、Q13627、Q8NEV1、Q9UGN5以及Q9Y6F1。