Premature activation of immune transcription programs in autoimmune-predisposed mouse embryonic stem cells and blastocysts

To study the underlying mechanism of autoimmunity predisposition in autoimmune-prone mouse strains, we characterize embryonic stem cells derived from various mouse strains. We performed mRNA-Seq analysis to determine the transcriptional differences between embryonic stem cells derived from auto-immune prone mouse strains. NOD: autoimmune-prone NZB: autoimmune-prone

为探究自身免疫易感小鼠品系中自身免疫易感性的潜在机制，我们对源自不同小鼠品系的胚胎干细胞进行了表征分析。本研究采用mRNA测序（mRNA-Seq）技术，以明确源自自身免疫易感小鼠品系的胚胎干细胞之间的转录组差异。非肥胖糖尿病小鼠（NOD）：自身免疫易感品系；新西兰黑鼠（NZB）：自身免疫易感品系。