Severe enteritis in dogs associated with single and mixed infections

ABSTRACT: Infectious enteritis is highly prevalent among dogs worldwide and, in some cases, it can be fatal. This study describes the clinical and laboratorial findings of single and mixed infections associated with severe enteritis in 76 dogs from Southern Brazil. Intestinal segments and/or fecal samples were subjected to histopathology and molecular detection of DNA viruses, bacteria and protozoa. Severe intestinal lesions were observed in most cases. Single infections were detected in 52.6% of cases, double (36.8%) and triple (10.5%) infections were also identified. Carnivore protoparvovirus 2 (CPV-2) was the most frequent agent in single infections (36.8%). Coinfection by CPV-2 and Giardia spp. was the most common in dual infections (19.7%), followed by CPV-2 and Cryptosporidium spp. (10.5%). The most frequent triple infection was CPV-2, Giardia sp. and Cryptosporidium spp. (6.6%). Our results shown that single and mixed infections are associated with severe enteritis in dogs in southern Brazil, mainly involving CPV-2 and Giardia sp.

摘要：犬传染性肠炎在全球犬群中流行率极高，部分病例可引发致命后果。本研究针对巴西南部76只出现重症肠炎的犬只，对其单一感染与混合感染的临床及实验室检测结果进行了报道。研究人员对肠段样本及/或粪便样本开展了组织病理学检查，并针对DNA病毒、细菌与原生动物进行了分子检测。多数病例可见重度肠道病变。单感染病例占比52.6%，另有36.8%为双重感染、10.5%为三重感染。食肉动物原细小病毒2型（Carnivore protoparvovirus 2，CPV-2）是单感染病例中最常见的病原体，占比达36.8%。CPV-2与贾第鞭毛虫属（Giardia spp.）混合感染是双重感染中最常见的类型（19.7%），其次为CPV-2与隐孢子虫属（Cryptosporidium spp.）混合感染（10.5%）。三重感染中最常见的为CPV-2、贾第鞭毛虫（Giardia sp.）与隐孢子虫属（Cryptosporidium spp.）混合感染，占比6.6%。本研究结果显示，巴西南部地区犬只的重症肠炎与单感染及混合感染密切相关，其中以CPV-2和贾第鞭毛虫（Giardia sp.）感染最为常见。