Network of hotspot interactions cluster tau amyloid folds

Datafiles associated with <strong>Network of hotspot interactions cluster tau amyloid folds.</strong> The alascan files contain the averaged and raw outputs of the <em>in silico </em>alanine scan conducted on tau fibrils. The combo aggregation file contains ThT fluorescence data from the VQIVYK/VEVKSE alanine mutants and coaggregation experiments. The incorporation_vs_insilico file contains the results of the alanine scan top and bottom hits compared to the results of the incorporation experiment of alanine mutants on that position.与<strong>用于tau淀粉样蛋白折叠聚类的热点相互作用网络</strong>相关的数据文件如下：丙氨酸扫描（alanine scan）文件包含了针对tau原纤维开展的<em>计算机模拟（in silico）</em>丙氨酸扫描的原始输出与平均输出结果；联合聚集文件收录了VQIVYK、VEVKSE丙氨酸突变体的硫黄素T（ThT）荧光数据，以及共聚集实验的相关结果；incorporation_vs_insilico文件则收录了丙氨酸扫描得到的高、低得分命中位点的结果，并将其与对应位置丙氨酸突变体的掺入实验结果进行对比后的分析数据。