Identification of FOXD2 as a chromatin tuning factor in intestinal stem cells and HCT116 cells (KAP220170)

This study delineates epigenomic and transcriptomic analysis of Forkhead box transcription factor FOXD2 in intestinal stem cell and colon cancer. By the anslysis of extensive mutiomics databases, FOXD2 was identified as a chromatin tuning factor to suppress cancer development. Here, we provide genome-wide maps of histone modifications and chromatin structures and interactions as well as gene expression profiles on FOXD2 overexpression.

本研究针对肠道干细胞与结肠癌中的叉头框转录因子FOXD2（Forkhead box transcription factor FOXD2）开展了表观基因组学与转录组学分析。通过对大规模多组学数据库的分析，FOXD2被鉴定为一类染色质调控因子，可抑制癌症发生发展。本研究提供了FOXD2过表达条件下的组蛋白修饰、染色质结构与相互作用的全基因组图谱，以及基因表达谱数据集。