ULK3 is a key determinant of the keratinocyte self-renewal and tumorigenesis through the targeting the arginine methylome
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The Vitamin D Receptor Is a Wnt Effector that Controls Hair Follicle Differentiation and Specifies Tumor Type in Adult Epidermis
We have investigated how Wnt and vitamin D receptor signals regulate epidermal differentiation. Many epidermal genes induced by β-catenin, including the stem cell marker keratin 15, contain vitamin D
NIAID Data Ecosystem80
Murine Kdm6a and Trp53 null squamous cell carcinoma
Cutaneous squamous cell carcinoma (cSCC) has among the highest mutation burdens of all cancers, reflecting its pathogenic association with the mutagenic effects of ultraviolet light exposure. Although
NIAID Data Ecosystem60
Epidermal fatty acid binding protein prevents chemical-induced skin tumorigenesis by inhibition of SOX2 expression in keratinocytes. Epidermal fatty acid binding protein prevents chemical-induced skin tumorigenesis by inhibition of SOX2 expression in keratinocytes
E-FABP expression in keratinocytes increase interferons, in particualur IFNlamda, expression, which activate P53, a critical tumor suppessor, to inhibit or prevent chemical-induced skin tumorigenesis.
NIAID Data Ecosystem30
IRF2 is a master regulator of human keratinocyte stem cell fate
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
NIAID Data Ecosystem80
Expression data from RhoA-null and wildtype keratinocytes. Mus musculus
Using mice with a keratinocyte-restricted deletion of the RhoA gene, we explored its role in the regulation of gene expression in vivo and in vitro Overall design: RNA was isolated from RhoA-null or w
NIAID Data Ecosystem50
