Regulatory T cell (T reg) function in HIV exposed seronegative (ESN) individuals. Homo sapiens

T reg frequency, activation and function was studied in ESN individuals. Between the subjects with a HIV-specific T cell response, we identified two groups, one, where the T regs were able to suppress T cell proliferation and one where they lacked this capability. Sorted T regs from this two groups were analysed for their expression pattern. Overall design: Nineteen samples with CD4+ T cell response were identified, in 11 of which Tregs were unable to suppress. Due to a low number of sorted cells, samples were run only one time.

本研究针对HIV暴露血清阴性（Exposed Seronegative, ESN）个体的调节性T细胞（T regulatory cells, Tregs）的频率、活化状态与功能展开了探究。
在携带HIV特异性T细胞应答的受试者中，我们鉴定出两个亚群：其中一组的Tregs可抑制T细胞增殖，另一组则不具备该功能。
我们对从这两组中分选获得的Tregs进行了表达谱分析。
实验设计概述：本研究共鉴定出19例具备CD4阳性T细胞应答的样本，其中11例样本中的Tregs无法抑制T细胞增殖。
由于分选得到的细胞数量有限，所有样本仅进行了单次检测。