Identification of Potential Biomarkers for Progressive Supranuclear Palsy Through RNA-Seq Analysis of Neural Precursor Cells Derived from Fibroblast-Generated iPSCs.

In this study, we generated novel RNA sequencing (RNA-seq) datasets from neural precursor cells derived from fibroblast-generated induced pluripotent stem cells (iPSCs) of patients with Progressive Supranuclear Palsy (PSP) and healthy controls, aiming to identify disease-associated genes and elucidate their potential pathophysiological roles in PSP.

本研究从进行性核上性麻痹（Progressive Supranuclear Palsy, PSP）患者及健康对照者的成纤维细胞诱导生成的诱导多能干细胞（induced pluripotent stem cells, iPSCs）分化所得的神经前体细胞中，构建了全新的RNA测序（RNA-seq）数据集，旨在识别疾病相关基因并阐明其在PSP中潜在的病理生理作用。