Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with Quisinostat

Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with Quisinostat Descriptor: 2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]-~{N}-oxidanyl-pyrimidine-5-carboxamide, GLYCEROL, Histone deacetylase DAC2, ... Authors: Marek, M, Ramos-Morales, E, Romier, C. Deposit date: 2021-10-18 Release date: 2021-12-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Rep, 37, 2021

克氏锥虫（Trypanosoma cruzi）组蛋白去乙酰化酶DAC2（Histone deacetylase DAC2）与喹司他（Quisinostat）复合物的晶体结构。配体描述：2-[4-[[(1-甲基吲哚-3-基)甲基氨基]甲基]哌啶-1-基]-N-羟基嘧啶-5-甲酰胺、甘油（GLYCEROL）、组蛋白去乙酰化酶DAC2等。作者：Marek, M、Ramos-Morales, E、Romier, C。沉积日期：2021-10-18；发布日期：2021-12-15；最后修改日期：2024-01-31。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.75埃（Å））。引用文献：《通过克氏锥虫组蛋白去乙酰化酶DAC2的非典型结构与活性位点实现病原体的物种选择性靶向》，发表于《Cell Reports》（Cell Rep）2021年第37卷。