Transcriptional profiling of liver, neutrophils and T cells from a mouse model of NASH-HCC

Transcriptional profiling by bulk RNA sequencing of murine livers or sorted immune cells, from DEN ALIOS NASH-HCC mouse model. Mice treated with CXCR2i (AZD5069) monotherapy, anti-PD1 monotherapy, or combination CXCR2i, anti-PD1 treatment. Published in doi: 10.1136/gutjnl-2021-326259 Expression data from liver and FACS purfied neutrophils and T cells

本数据集基于DEN-ALIOS诱导的非酒精性脂肪性肝炎-肝细胞癌（NASH-HCC）小鼠模型，采用批量RNA测序（bulk RNA sequencing）对小鼠肝脏或分选免疫细胞进行转录组谱分析。实验小鼠分别接受CXCR2抑制剂（CXCR2i，AZD5069）单药治疗、抗PD-1（anti-PD1）单药治疗，以及CXCR2抑制剂联合抗PD-1的联合治疗方案。该研究已发表于DOI：10.1136/gutjnl-2021-326259，数据集表达数据涵盖肝脏样本以及经荧光激活细胞分选（FACS）纯化的中性粒细胞和T细胞的转录组信息。