Prediction of platinum-based neoadjuvant chemotherapy response in muscle-invasive bladder cancer using a multifaceted approach

Dataset This dataset contains gene-level RNA sequencing count matrices and associated metadata generated from bladder cancer samples analyzed in two experimental phases. The data were produced to investigate transcriptional differences in tumor samples collected during transurethral resection of bladder tumor (TUR-BT) procedures. Data Contents The repository includes: Gene-level count matrix for whole-transcriptome RNA sequencing samples (paired-end sequencing, Discovery phase-1) Gene-level count matrix for targeted RNA expression sequencing samples (single-end sequencing, Validation phase-2) Sample metadata describing sample identifiers and experimental groups All count matrices contain raw read counts and have not been normalized. Reference Genome and Annotation Human reference genome: GRCh38 primary assemblyGene annotation: GENCODE release v48 Software R v.4.4.0 Bioconductor package Rsubread (v2.18.0) featureCounts (Rsubread)数据集 本数据集包含从两个实验阶段完成分析的膀胱癌样本中生成的基因级RNA测序计数矩阵及配套元数据。本数据旨在探究经尿道膀胱肿瘤切除术（transurethral resection of bladder tumor, TUR-BT）术中采集的肿瘤样本的转录组差异。 数据内容 本数据集仓库包含以下内容： - 全转录组RNA测序样本的基因级计数矩阵（双端测序，发现阶段1） - 靶向RNA表达测序样本的基因级计数矩阵（单端测序，验证阶段2） - 描述样本标识符与实验组信息的样本元数据 所有计数矩阵均包含原始读段计数，且未经过标准化处理。 参考基因组与注释 人类参考基因组：GRCh38 主要组装版本 基因注释：GENCODE 发布版本v48 软件工具 R v.4.4.0 Bioconductor 软件包 Rsubread（v2.18.0） featureCounts（基于Rsubread实现）