Pregnancies with extreme fetal-maternal HLA incompatibility

Pregnancy requires local immune tolerization. Oocyte donation (OD) pregnancies, with extensive fetal-maternal HLA mismatching, are at higher risk of pre-eclampsia. We hypothesize that immune adaptations are needed at the fetal-maternal interface to maintain healthy pregnancy despite high HLA dissimilarity. This study is by X. Tian et al. The data sets concern raw HLA genotyping data, imaging mass cytometry data and RNA sequencing data generated from decidua basalis of fully-allogeneic healthy pregnancies, semi-allogeneic healthy pregnancies, and fully-allogeneic pregnancies with pre-eclampsia.

妊娠需要建立局部免疫耐受。卵母细胞捐赠（Oocyte Donation, OD）妊娠的胎儿与母体间存在广泛的人类白细胞抗原（Human Leukocyte Antigen, HLA）错配，其子痫前期（pre-eclampsia）发病风险显著升高。本研究提出假说：即便胎儿与母体间人类白细胞抗原差异度较高，胎儿-母体界面仍需发生免疫适应性改变以维持健康妊娠。本研究由X. Tian等人开展，数据集涵盖源自三类妊娠个体底蜕膜（decidua basalis）的原始人类白细胞抗原基因分型数据、成像质谱流式细胞术（imaging mass cytometry）数据与RNA测序（RNA sequencing）数据，三类妊娠分别为完全同种异体健康妊娠、半同种异体健康妊娠，以及伴子痫前期的完全同种异体妊娠。