Gene expression profiling in PA1 ovarian cancer cells under anchorage independence either in the presence of vehicle or BMP9 treatment for 24 hours. Gene expression profiling in PA1 ovarian cancer cells under anchorage independence either in the presence of vehicle or BMP9 treatment for 24 hours

BMP9 promotes anoikis sensitivity in cancer cell lines. Here we examine the changes in gene expression in response to BMP9 in cells under anoikis to identify potential pathways associated with anoikis sensitivity. Overall design: 6 total samples were analyzed. We performed a pairwise comparison of PA-1 cell line in presence or absence of BMP9. Genes with a p-valued < 0.05 and a fold-change ≥ 2.0 were selected.

骨形态发生蛋白9（BMP9，bone morphogenetic protein 9）可增强癌细胞系的失巢凋亡（anoikis）敏感性。本研究旨在检测失巢凋亡状态下细胞响应BMP9的基因表达变化，以筛选与失巢凋亡敏感性相关的潜在信号通路。实验整体设计：共计分析6份样本。我们对PA-1细胞系在添加与不添加BMP9的条件下进行了成对比较分析。最终筛选出p值小于0.05且倍数变化≥2.0的差异表达基因。