Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex.

Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally flexible covalent enzyme-substrate complex. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ecto-NAD+ glycohydrolase (CD38 molecule), SULFATE ION Authors: Egea, P.F, Muller-Steffner, H, Stroud, R.M, Oppenheimer, N, Kellenberger, E, Schuber, F. Deposit date: 2009-02-21 Release date: 2010-03-02 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. Plos One, 7, 2012

CD38催化机制的结构解析：构象柔性共价酶-底物复合物的实验证据。描述符：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1-4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、胞外NAD+糖水解酶（Ecto-NAD+ glycohydrolase，即CD38分子）、硫酸根离子。作者：Egea, P.F.、Müller-Steffner, H.、Stroud, R.M.、Oppenheimer, N.、Kellenberger, E.、Schuber, F.。提交日期：2009年2月21日；发布日期：2010年3月2日；最后修改日期：2024年11月6日。实验方法：X射线衍射（1.51 Å）。引用文献：《基于牛CD38/NAD+糖水解酶的米氏复合物与共价捕获中间体的X射线结构解析其催化机制》，《公共科学图书馆·综合》，第7卷，2012年。