Intercellular nanotube-mediated mitochondrial transfer enhances T-cell metabolic fitness and antitumor efficacy

We found that bone marrow-derived mesenchymal stromal cells (MSC) establish nanotubular connections with T cells in a Talin 2 (TLN2)-dependent manner and leveraged these intercellular highways to supply new mitochondria to CD8+ T cells. In this experiment we analyzed the transcriptional profile of T cells co-cultured with MSC containing MSC derived Mitochondria (MitoPositive), T cells co-cultured with MSC not containing MSC derived Mitochondria and control T cells.EGA study EGAS00001007356

我们发现，骨髓来源间充质基质细胞 (bone marrow-derived mesenchymal stromal cells) 可通过依赖踝蛋白2 (Talin 2) 的方式与T细胞形成纳米管状连接，并借助此类细胞间通路向CD8阳性T细胞递送新生线粒体。本实验对三类样本的转录组谱进行了分析：与携带有MSC源性线粒体的MSC共培养的T细胞（MitoPositive组）、与未携带有MSC源性线粒体的MSC共培养的T细胞，以及对照T细胞。本数据集关联EGA (European Genome-phenome Archive) 研究EGAS00001007356。