Addition of intravenous midazolam to lignocaine hydrochloride for peribulbar block among people undergoing cataract surgery: A longitudinal study

Aim:
To determine the efficacy of intravenous midazolam addition to lignocaine hydrochloride as an adjuvant to peribulbar block

Methods:
A longitudinal, time-bound study with detailed history, anterior segment evaluation (preoperatively and postoperatively) with applicable patients divided into two groups: one group (A) received intravenous midazolam 5 minutes prior to peribulbar block, the other group (B) received only peribulbar block. Every patient received instruction on how to measure their anxiety using the Global Anxiety Visual Analogue Scale, and their pain using the Wong Baker Faces Pain Rating scale. Vital baseline measures like heart rate, blood pressure, respiratory rate, and oxygen saturation were collected.

Results:
A total of 88 patients were included in the study. Group A and Group B had 44 participants each. Group A noted lower heart rate, lower systolic BP, lower respiratory rate, along with reduction in pain and anxiety that was found to be statistically significant, as compared to Group B.

Conclusion:
Incorporating intravenous midazolam prior to local anesthetic in peribulbar block results in a notable decrease in patient anxiety and pain perception throughout the treatment, without generating any substantial negative effects on the cardiovascular system.

研究目的：旨在探究将静脉注射咪达唑仑作为盐酸利多卡因（lignocaine hydrochloride）佐剂用于球周阻滞麻醉（peribulbar block）的疗效。

研究方法：本研究为一项时限性纵向研究，采集患者详细病史，于术前及术后开展眼前节评估；将符合入组标准的患者分为两组：A组于球周阻滞麻醉前5分钟静脉注射咪达唑仑，B组仅接受球周阻滞麻醉。所有患者均接受指导，掌握使用总体焦虑视觉模拟评分法（Global Anxiety Visual Analogue Scale）评估自身焦虑程度，以及使用Wong-Baker面部表情疼痛评分量表（Wong Baker Faces Pain Rating scale）评估疼痛程度的方法，并采集心率、血压、呼吸频率及血氧饱和度等核心基线指标。

研究结果：本研究共纳入88例患者，A、B两组各44例。与B组相比，A组患者的心率、收缩压及呼吸频率均更低，疼痛与焦虑程度均显著降低，且差异具有统计学意义。

研究结论：在球周阻滞麻醉的局部麻醉药物给药前联用静脉注射咪达唑仑，可显著降低患者在整个治疗过程中的焦虑程度与疼痛感知，且不会对心血管系统产生明显不良影响。