Supplementary Table S2 from Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes

PTM peak data and phenotype 47 fragment variability
Sheet 1: PDX sample representation in 3 histone PTM CUT&RUN nucleosome profiling assays (H3K4me1, H2K27ac and H3K27me3).
Sheet 2: Log2 fold-change, p-value, and q-value between ARPC and NEPC lines for coefficient of variation in the 47 phenotype defining gene bodies (two tailed Mann-Whitney U test, Benjamini-Hochberg adjusted).
Sheet 3: Log2 fold-change, p-value, and q-value between ARPC and NEPC lines for coefficient of variation in the 47 phenotype defining gene promoters (two tailed Mann-Whitney U test, Benjamini-Hochberg adjusted).

本数据集涵盖翻译后修饰（Post-translational Modification, PTM）峰数据与47个表型定义片段变异信息，包含以下3个工作表：
工作表1：3种组蛋白PTM的CUT&RUN（Cleavage Under Targets and Release Using Nuclease, CUT&RUN）核小体谱分析实验（涉及H3K4me1、H2K27ac及H3K27me3三种修饰）中的患者来源异种移植模型（Patient-Derived Xenograft, PDX）样本表征情况。
工作表2：47个表型定义基因体中，ARPC（Androgen Receptor-Positive Prostate Cancer, ARPC）与NEPC（Neuroendocrine Prostate Cancer, NEPC）细胞系的变异系数对应的log₂倍变化、p值及q值（双侧曼-惠特尼U检验（Mann-Whitney U test），经Benjamini-Hochberg校正（Benjamini-Hochberg adjustment））。
工作表3：47个表型定义基因启动子区域中，ARPC与NEPC细胞系的变异系数对应的log₂倍变化、p值及q值（双侧曼-惠特尼U检验，经Benjamini-Hochberg校正）。