Native ECM in obesity visceral adipose tissue initiates human adipose stem cell senescence via TGF-beta and mitochondrial signaling

Background & Aims: Obesity is a complex disease that causes visceral WAT dysfunction and is associated with cardiovascular, chronic inflammatory and other metabolic pathologies.Adipose-derived stem cells (ASCs) are the key cells for adipose tissue homeostasis.However, how obesity may affect the biological functions of hASCs is not clear. We then performed gene expression profiling analysis using data obtained from RNA-seq of 8 different donors obese group,and 3 different donors lean group Comparative gene expression profiling analysis of RNA-seq data for 8 different donors obese group, and 3 different donors lean group

研究背景与目的：肥胖是一种复杂疾病，可引发内脏白色脂肪组织（visceral white adipose tissue, WAT）功能异常，并与心血管疾病、慢性炎症及其他代谢性病理状态密切相关。脂肪来源干细胞（adipose-derived stem cells, ASCs）是维持脂肪组织稳态的关键细胞群。然而，肥胖如何影响人类脂肪来源干细胞（human adipose-derived stem cells, hASCs）的生物学功能，目前尚不明确。本研究针对8名肥胖组受试者与3名正常体重对照组受试者的RNA测序（RNA-seq）数据，开展了比较基因表达谱分析。