Raw Data for: Phenotypic and Functional Outcomes in Macrophages Exposed to an Environmentally Relevant Mixture of Organophosphate Esters in vitro

This dataset contains the compiled raw data and image analysis coding for the main and supplemental figures seen in “Phenotypic and Functional Outcomes in Macrophages Exposed to an Environmentally Relevant Mixture of Organophosphate Esters in vitro”. Organophosphate esters (OPEs) are flame retardants and plasticizers used in consumer products. OPEs are found ubiquitously throughout the environment with high concentrations in indoor house dust. Exposure to individual OPEs is associated with immune dysfunction, particularly in macrophages. However, OPEs exist as complex mixtures and the effects of environmentally relevant mixtures on the immune system have not been investigated. The objectives of this study were to evaluate the toxicity of an environmentally relevant mixture of OPEs that models Canadian house dust on macrophages using phenotypic and functional assessments in vitro.

本数据集涵盖发表于《体外暴露于环境相关有机磷酸酯（Organophosphate esters, OPEs）混合物的巨噬细胞表型与功能结局》一文中的主图及补充图所对应的汇编原始数据与图像分析编码。有机磷酸酯（OPEs）是一类应用于消费品的阻燃剂与增塑剂，在环境中广泛分布，且在室内家居粉尘中检出浓度较高。现有研究显示，单一OPEs暴露与免疫功能异常存在关联，尤以巨噬细胞为显著。然而，OPEs多以复杂混合物形式存在，目前尚未有针对环境相关浓度混合物对免疫系统影响的研究。本研究的目的为，通过体外表型与功能评估方法，评估模拟加拿大家居粉尘的环境相关浓度OPEs混合物对巨噬细胞的毒性作用。