Colom_Dataset_SynapticPasticityofSignTrackerRats.csv

When attributed with motivational salience, reward-predictive stimuli can drive behaviour and contribute to maladaptive responses. We examined whether sign-tracking conditioned behaviours were associated with specific dendritic spine features, as well as markers of pre- and postsynaptic activity in the nucleus accumbens core of male and female rats. Data suggest that changes in accumbal neuronal plasticity may be related to individual variation in the responsiveness to Pavlovian cues.

当被赋予动机显著性时，奖励预测刺激可驱动行为并促成适应不良反应。本研究探讨了信号追踪条件行为是否与特定树突棘 (dendritic spine) 特征，以及雌雄大鼠伏隔核核心区 (nucleus accumbens core) 的突触前后活动标志物相关。数据表明，伏隔核神经元可塑性的变化可能与个体对巴甫洛夫线索的反应性差异有关。